Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,846 – 4,860 of 60,549 results

4,846

TARGETMOL CHEMICALS INC YLF-466D 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. YLF-466D (C24) is a newly developed AMPK activator which inhibits platelet aggregation. purity: 98%

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4,847

Cayman Chemical ANTIBODY14 15-EET 100UG

An arachidonic acid metabolite; formed via epoxidation of arachidonic acid by cytochrome P450; prevents increases in LTB4, ICAM-1, and CCL2 induced by oxidized LDL in primary RPAECs at 1 μM; induces dilation of preconstricted isolated canine coronary arterioles (EC50 = 0.2 pM); reduces myocardial infarct size as a percentage of the area at risk in a canine model of ischemia-reperfusion injury induced by LAD occlusion at 0.128 mg/kg prior to occlusion or reperfusion

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4,848

Cayman Chemical MIK665, Purity: ≥98%, CAS: 1799631-75-6, 1 mg

An Mcl-1 inhibitor (Ki = 1.2 nM)

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4,849

Medchemexpress LLC RBP4 inhibitor 1 | 1198180-03-8 | 99.7% | 357.25 | C14H13F6NO3 | 5 MG

RBP4 inhibitor 1 is a potent, orally active retinol-binding protein 4 (RBP4) inhibitor reported to reduce blood RBP4 levels in vivo. It exhibits low-nanomolar activity against human RBP4 and is supplied as a high-purity research compound.

Potent RBP4 inhibition: IC50 28 nM (human), 110 nM (mouse).
High purity: 99.74%.
Appearance: white to off-white solid.
Molecular weight: 357.25 g/mol.
Chemical formula: C14H13F6NO3.
SMILES string provided for structural reference.
Storage: powder at -20°C (stable for 3 years); in solvent -80°C for 6 months, -20°C for 1 month.
Available in small research pack sizes and DMSO solutions for screening.

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4,850

Cayman Chemical BAY 55-9837 (trifluoroacetate salt), Purity: ≥98%, 5 mg

A VPAC2 agonist; binds to VPAC2 (Kd = 65 nM) and selectively induces cAMP production in CHO cells expressing human VPAC2 over VPAC1 or PAC1 receptor (EC50s = 0.4, 100, and >1,000 nM, respectively); increases glucose-dependent insulin secretion in isolated rat and human pancreatic islets at 100 nM; enhances glucose-induced insulin secretion in fasted rats (ED50 = ~3 pmol/kg)

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4,851

Apexbio Technology LLC PFK-015 4382-63-2 10mM (in 1mL DMSO)

PFK-015 (CAS 4382-63-2) is a selective inhibitor of 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 (PFKFB3) with an IC50 of 207 nM PFKFB3 regulated by HIF- and activated by oncogenic signaling pathways such as AKT and Ras plays a key role in glycolytic flux and tumor metabolism In cellular assays PFK-015 exhibits cytotoxic effects in lung adenocarcinoma (H522) and leukemia (Jurkat) cell lines suppressing glucose uptake intracellular ATP and F2 6BP levels It promotes apoptosis in Jurkat cells and reduces metastatic spread in a Lewis lung carcinoma mouse model PFK-015 is utilized in cancer research to investigate glycolysis inhibition as a therapeutic strategy

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4,852

Medchemexpress LLC GNE-617 hydrochloride | 1362154-70-8 | ≥98.0% | 427.42 g/mol | C21H15F2N3O3S | 10 MG

GNE-617 hydrochloride is a potent, selective small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with reported biochemical potency in the low nanomolar range. It is supplied as the hydrochloride salt and is used for in vitro NAMPT assays, antiproliferative studies, and in vivo xenograft models.

Potent NAMPT inhibition (IC50 ≈ 5 nM).
Hydrochloride salt supplied as a solid powder.
Typical purity ≥98% (supplier dependent).
Molecular formula C21H15F2N3O3S; molecular weight 427.42 g/mol.
Suitable for in vitro and in vivo cancer biology research.
CAS number 1362154-70-8.

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4,853

Medchemexpress LLC 2-(S)-(3,5-bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid | 1146594-87-7 | 99.5% | 480.44 | C26H22F6O2 | 1 MG

JNJ-40418677 is a small-molecule γ-secretase modulator used in preclinical Alzheimer's disease research. It is orally active and brain-penetrant, and has been shown to selectively lower amyloid β42 production and reduce plaque burden in animal models, while sparing Notch processing.

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4,854

Cayman Chemical TA-02, Purity: ≥98%, CAS: 1784751-19-4, 5 mg

An inducer of cardiomyocyte differentiation; increases expression of the cardiomyocyte marker NKX2-5 by >2-fold and decreases expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells at 5 μM; inhibits CK1ε and CK1D and reduces expression of Wnt/β-catenin signaling pathway members

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4,855

Cayman Chemical LDN-192960 (hydrochloride), Purity: ≥98%, CAS: 2309172-48-1, 50 mg

An inhibitor of haspin and DYRK2 (IC50s = 10 and 48 nM, respectively); selective for haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC50s = 720-91,000 nM)

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4,856

Medchemexpress LLC LDN-209929 dihydrochloride | 1784281-97-5 | MFCD28133376 | 98.3% | 405.77 g/mol | C17H19Cl3N2OS | 5 MG

LDN-209929 dihydrochloride is the dihydrochloride salt of a potent, selective small-molecule inhibitor of haspin kinase (reported IC50 = 55 nM) with approximately 180-fold selectivity over DYRK2. Supplied as a yellow-orange solid for biochemical and cellular research, it is commonly provided in small research pack sizes and is typically ≥98% pure.

Potent haspin kinase inhibition (IC50 = 55 nM).
Approximately 180-fold selectivity versus DYRK2.
Dihydrochloride salt, solid, yellow to orange.
Molecular weight 405.77 g/mol.
Purity approximately 98.3% by HPLC.
Storage: 4°C sealed; in solvent -80°C for 6 months, -20°C for 1 month.
Available in small research sizes including 5 mg.

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4,857

TARGETMOL CHEMICALS INC FIN56 25MG

Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. FIN56 is a specific inducer of ferroptosis. purity: 99%

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4,858

Cayman Chemical DL-Glyceraldehyde-3-phosphate, CAS: 591-59-3, 5 mg

An intermediate in several metabolic pathways, including glycolysis and gluconeogenesis

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4,859

Medchemexpress LLC Tubulysin M | 936691-46-2 | 1 MG

Tubulysin M is a highly cytotoxic anti-microtubule toxin, isolated from myxobacteria Archangium geophyra and Angiococcus disciformis. It is synthesized as an ADC cytotoxin and exhibits potent activity against various mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range.

Inhibits microtubule/tubulin polymerization
Leads to cell cycle arrest and apoptosis
Active against multidrug-resistant cell lines
Binds to vinca domain and tubulin β2 subunit

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4,860

Cayman Chemical A-769662, Purity: ≥98%, CAS: 844499-71-4, 5 mg

A direct activator of AMPK (EC50 = 116 nM in a cell-free assay); allosterically activates AMPK and inhibits its dephosphorylation on Thr172; activates β1 subunit-containing AMPK heterotrimers; has been used to stimulate CYP450-mediated fatty acid oxidation, inhibit adipocyte differentiation, explore glucose uptake in skeletal muscle, and promote endothelial cell survival during metabolic stress

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Bioactive Small Molecules

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Medchemexpress LLC RBP4 inhibitor 1 | 1198180-03-8 | 99.7% | 357.25 | C14H13F6NO3 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC GNE-617 hydrochloride | 1362154-70-8 | ≥98.0% | 427.42 g/mol | C21H15F2N3O3S | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2-(S)-(3,5-bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid | 1146594-87-7 | 99.5% | 480.44 | C26H22F6O2 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC LDN-209929 dihydrochloride | 1784281-97-5 | MFCD28133376 | 98.3% | 405.77 g/mol | C17H19Cl3N2OS | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Tubulysin M | 936691-46-2 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC RBP4 inhibitor 1 | 1198180-03-8 | 99.7% | 357.25 | C14H13F6NO3 | 5 MG

Medchemexpress LLC GNE-617 hydrochloride | 1362154-70-8 | ≥98.0% | 427.42 g/mol | C21H15F2N3O3S | 10 MG

Medchemexpress LLC 2-(S)-(3,5-bis(4-(trifluoromethyl)phenyl)phenyl)-4-methylpentanoic acid | 1146594-87-7 | 99.5% | 480.44 | C26H22F6O2 | 1 MG

Medchemexpress LLC LDN-209929 dihydrochloride | 1784281-97-5 | MFCD28133376 | 98.3% | 405.77 g/mol | C17H19Cl3N2OS | 5 MG

Medchemexpress LLC Tubulysin M | 936691-46-2 | 1 MG